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House vacation rentals in Des Moines
Find and book unique houses on Airbnb
Top-rated house rentals in Des Moines
Guests agree: these houses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Des Moines house rentals
House rentals with free parking
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The Cow Tipper: Spa • Game Room • BBQ • Fire Pit
Matthew was very easy to communicate with leading up to the stay and also during the stay. We had no problems with our stay and everything was as described. The house was easy to get to and the neighborhood was quiet.
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The Red Door ❤ WiFi Coffee Comfort Style
1:) Clean environment 2:) Safe and quiet location 3:) Quick response to your question 4:) half mile to downtown 5:) Very organized Red Door is the best 🤝🌟🌟🌟🌟🌟

Cozy 4br Home - Close To Downtown!
Very peaceful and big space. Felt like home.
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Cozy home with 4 bedroom in Urbandale
Perfect spot for our group of 8 (4 adults, 4 kids) on a weekend trip to visit family in Des Moines. Good space, clean, and very responsive hosts.

Downtown Townhome w skyline view
Hands-down, the best place I’ve stayed in Des Moines. That goes for our hostess Bry as well.

Rest At Ease in Ankeny
My family and I felt right at home the moment we stepped in the door. It was a cute, cozy, and very clean space to hangout during our stay in Ankeny. Stephanie responded right away when I had questions and was accommodating to our needs. Would totally stay here again!
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Your home away from home.
Great host. Very friendly and helpful, checked in a few times to make sure my family and I were doing good. Welcoming, beautiful and peaceful home. Would definitely go back if ever needed.
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Modern Ranch near Knapp Center, Stadium, Downtown
We enjoyed our stay, easy access to different areas of town. Photos were accurate as well.
House rentals with a pool
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Comfortable and Spacious Five Bedroom Home
Beautiful large home was very clean and comfortable for our family stay. The grandkids enjoyed the pool! The kitchen was well stocked and had everything you need to prepare meals of any kind - including grilling. Would highly recommend this to groups/large families.
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West Des Moines modern mansion!
We rented the main house and the guest house and our stay was fantastic. If you are looking for a property where you and your friends/family can have a great time without having to leave the house this is it! Robert was easy to get in touch with whenever we had questions and everything was as described. We really enjoyed hanging out by the pool and cooking in the high tech kitchen. If we come back to this area we will definitely be renting this house again!
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New Remodel! Family Fun House
Colby is responsive, approachable, and his ability to meet our needs was outstanding. It was easy to check in and out. Amenities were endless and the property had everything. Would definitely return.
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Travel Haven - 6 Beds, 5 BR, 3 Bath, Near I-35
Would definitely stay again! We had a late family Christmas (meet up in the middl states wise) and they even left a Christmas tree up 🤩 we enjoyed a hockey game in town and enjoyed having the hot tub to warm up after! Plenty of restaurants and shopping nearby as well 💯.
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New Neat Nascent & Neighborly
Great location...close to food, shopping and the RecPlex. Townhouse was immaculate and exactly like the pictures. Quiet neighborhood. I would definitely stay again.

The Estate
Great location, very clean, and all the extra amenities were so appreciated . The hot tub was wonderful. Beautifully furnished and updated. It was perfect…we wished we could have stayed longer! Highly recommend!
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Hot Tub Hideaway Awaits! March Discounts!
The entire stay was great and the host was very responsive!
Weekly house rentals
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Hot Tub Haven: Large Home with Game Room & Privacy
Able to locate easily, in nice neighborhood. Our group had a lot of fun, and the host was easy to communicate with!

Cute 2-bedroom / 1 bath house completely remodeled
Very comfortable bed and couch, the TVs were awesome and the living area was surprisingly spacious. Neighborhood is peaceful and centrally located in Des Moines with Beaverdale and downtown Drake a short distance away.

Comfy Beds • Washer/Dryer • Pet Friendly
Quiet neighborhood & the cozy home had the necessities we required. The hosts were friendly.
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Waukee Guest House - Close to everything in DSM
Unbelievable stay, with a 5 star Host and place. We were more than comfortable and Joseph went above and beyond our needs and even went over the top to make sure we were comfortable and taken care of. Awesome gift basket on our arrival and can’t say enough good things about him, the house and the stay. 100 percent coming back to this place when we come back later this year or early next.
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Saylorvilla ~ Tesla Charger
I really loved this Airbnb!! I can see why it’s so highly rated. It’s so homey and comfortable, great for groups! Bringing our pups was a huge plus. Most dog friendly Airbnb’s aren’t that great but Jen’s place was perfect and spotless. The neighborhood was very safe and a great place to walk the dogs! We would definitely stay again!
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Gateway House
Excellent stay & A+ hosts. The house is super close to great restaurants and breweries and is right off I-235 so super easy to get around. Steve and Angie were super communicative, helpful, flexible…everything was easy. The house is stocked with everything you could need. We had a great time and would stay again.
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The Glenda! Sassy West Glen Home + Garage
Danielle was an amazing host! The home was just as described, and perfect for our group. The location was great as we could walk to dinner and it was easy to get to! I highly recommend staying here! You won’t be disappointed. The home is gorgeous and there is so much room to spread out! Anything we may have forgotten she had and the kitchen was stocked with everything we needed to cook breakfast, ie.,(silverware, plates, bowls, ect) if we are ever in need to stay in Des Moines this will be our first choice!
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Home in Waukee
My friends and I stayed for one night and had a great time! There was enough space for everyone! We didn’t feel crowded! The place is spacious even when we didn’t get to use the basement or garage to park, that was no problem! Very clean. I loved the introduction book with house rules and recommendations! There was a tiny issue we noticed upon arrival and Trisha responded quickly! I would recommend and definitely come back if ever in the area!
Quick stats about house rentals in Des Moines
Total rentals
410 properties
Total number of reviews
22K reviews
Family-friendly rentals
290 properties are a good fit for families
Pet-friendly rentals
170 properties allow pets
Rentals with dedicated workspaces
250 properties have a dedicated workspace
Wifi availability
400 properties include access to wifi
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