Vacation home rentals in Panama

Find and book unique vacation home rentals on Airbnb

Top-rated vacation home rentals in Panama

Guests agree: these vacation home rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Vacation home in Anton Valley

4.91 out of 5 average rating, 54 reviews

Adorable 2 bedroom home near India Dormida hiking

This fully equipped 2 bedroom home has been a high-rated Super Host Airbnb favorite for 5 years. It now has an equally fabulous new owner and Airbnb requires a fresh start. Relax into the hammocks in this peaceful residential setting with views of India Dormida and the picturesque Iguana mountain from your covered veranda. A short walk through the authentic Panamanian neighborhood to the town (~ 1 mile) with shops, restaurants, and daily Farmers Market with fresh fruits/vegetables & local crafts

Guest favorite

Vacation home in Chitré

4.96 out of 5 average rating, 49 reviews

CASA EdditA ° Acogedora casa en Chitré

° HOUSE EDDITA ° Fully equipped house for your enjoyment. Spacious, cool and cozy in one of the best located residential areas of Chitré, close to everything: supermarkets, casinos and bus terminal. If you are thinking of touring Azuero we suggest making a stop at Casa Eddita, getting to know the center of Chitré, its handicrafts, the cathedral and its variety of typical meals; from here you will be just 1:30 hr from the best beaches in Azuero in Pedasí (Playa Venao and Isla Iguana). Welcome!

Superhost

Vacation home in Maria Chiquita

4.84 out of 5 average rating, 32 reviews

Dreamy, Modern Caribbean Home at Playa Escondida

Have fun with the whole family at Casa Capri, a dreamy place which is a perfect fit both for adults & kids. The apartment is at Playa Escondida, a stylish resort with white sand beaches and crystal clear ocean water, several amenities such as a restaurant (with a broad range of great food, including fresh seafood and sushi!), pools to chill or swim, plus fantastic and diverse children playgrounds. Whether you'd like to have a resting vacation or a fun getaway, Casa Capri got you covered. Enjoy!

Guest favorite

Vacation home in Bocas del Toro

5 out of 5 average rating, 57 reviews

The Pool House Too, Beach House on Paunch Beach

The Pool House Too is a gorgeous one bedroom hideaway steps from the beach at Paunch, one of Bocas' most beautiful surf beaches. The house has a private plunge pool within lush tropical gardens, air-conditioned bedroom, comfortable lounge with TV, fully equipped kitchen, both en-suite bathroom and guest half bathroom, and a covered outside lounge/dining area. There is a washer and dryer, private covered parking and good WiFi. There are 7 restaurants/cafes within walking distance of the house.

Guest favorite

Vacation home in Panama City

5 out of 5 average rating, 36 reviews

Luxury Apartment With Private Beach And Sea View

Apartment with stunning beach and sea views The resort is surrounded by a beautiful rainforest and natural wildlife. It is a unique tropical oasis with beachfront condominiums adjacent to a neighboring five-star hotel.The Playa Bonita Village resort is located amidst a beautiful rainforest and natural wildlife on an exclusive private beach, adjacent to the Westin Hotel and is just 15 minutes from the city. The resort enjoys beautiful views of the rainforest and the Pacific Ocean.

Superhost

Vacation home in Juan Gallego

4.85 out of 5 average rating, 89 reviews

Pebos Reef, 12 guests, Amazing views!!

This spectacular beachfront property is ideally situated with an incredible view of neighboring islands, fishing friendly waters, and mesmerizing snorkeling spots for children and adults to enjoy. Monkey greetings from the jungle adjacent, octopus and colorful native fish inhabited waters, and lazy bear sloth sightings are all part of your daily experiences here at Pebos Reef! If you are lucky you will even see dolphins from the terrace ! A terrace on the sea is all you need.

Guest favorite

Vacation home in Bocas del Toro

4.94 out of 5 average rating, 32 reviews

Jungle house under the giants at the Bluff Beach

NEW OPENING: October 2022 Enjoy your vacation in the rustic jungle house as a nature and beach lover directly under rainforest giants. The cottage sleeps 4 pers in 2 bedrooms, with outdoor kitchen on the covered terrace and an outdoor bathroom with warm rainforest shower, wooden bathtub with whirlpool and double sinks. Experience the jungle up close with exotic birds, howler monkeys, sloths and ocean sounds. Only 2 minutes/200m from the mile long sandy beach.

Guest favorite

Vacation home in Bocas del Toro

4.97 out of 5 average rating, 31 reviews

SEA VIEW @ Casa Rosada Feel the Breeze....

STUNNING OCEAN VIEW HOME IN PLAYA PAUNCH! A Surfer's Dream - Tiger Tail is Right Outside your Front Door. Dynamic Ocean Views from the Comfort of your Private Terrace. Entertaining Monkey Antics are Enjoyable from the Rear, Jungle View Entrance. 10 minutes from Town and Steps Away from Great Surfing, Gorgeous Wading Pools, Snorkeling, Diving & 6 Great Dining Options. A Comfortable Place to Launch All Your Adventures or Just Sit and Enjoy The Lush Scenery.

Guest favorite

Vacation home in Maria Chiquita

4.94 out of 5 average rating, 80 reviews

**Playa Escondida - Paradise in the caribbean sea

Playa Escondida is a jewel in the Caribbean with white sand and surrounded by turquoise water and full of green. The apartment is super comfy, with all amenities for a perfect stay. The condo counts with a great infrastructure, including a restobar, a shawarma grill, sushi bar and a convenience store. There is a wonderful swimming pool; 2 lagoons suitable for swimming; a football (5p) court; gym and plenty of space for you to walk along safe and sound.

Guest favorite

Vacation home in San Carlos

4.89 out of 5 average rating, 37 reviews

Welcome to our house in Playa Corona

Relax with the whole family in this quiet place and spend a few days of vacation as you deserve * Power Plant/Water tank! The beautiful Corona Beach has miles of white sand and beautiful scenery that you can also enjoy from the deck O from the cozy pool or reading a good book and with your favorite music. From your kitchen, prepare delicious dishes that you can complement with the outdoor BBQ If your group is 2 to 4 people, we offer special rates

Guest favorite

Vacation home in Rio Hato

5 out of 5 average rating, 18 reviews

Nice apto in benaventura

Create unforgettable memories at this unique and family home. In Marina Village you will enjoy a wonderful, quiet stay with a nice view of the sea. A comfortable and cozy apartment where you will feel at home, you can relax and enjoy with the family of a few days with all the comforts. The apartment has a spacious bedroom with a king-size bed, a sofa bed in the living room for 2 people, and a couple of additional options for sleeping.

Guest favorite

Vacation home in Maria Chiquita

5 out of 5 average rating, 18 reviews

Playa Escondida, Vista al Mar

Relax with the whole family in this quiet place to stay. Enjoy the EXCLUSIVITY that our residences offer you and the common areas of this paradise place... Playa Caribeña, no waves and flat (perfect for small children), sand in Las Bahamas and with the greatest safety and cleanliness you deserve. Don't miss the chance to have your favorite moonlit drink by the beach (near the reflectors).