Hotel vacation rentals in Panama
Find and book unique hotel rentals on Airbnb
Top-rated hotel rentals in Panama
Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama hotel rentals
Family-friendly hotel rentals
Nature lodge in Darién Province
4.67 out of 5 average rating, 18 reviewsNo Chunga
Nature lodge in Cébaco
4.57 out of 5 average rating, 14 reviewsIsland Lodge Retreat Cebaco Sunrise/Cebaco Island
Aparthotel in Alto Boquete
4.67 out of 5 average rating, 21 reviewsCabañas Villa San Miguel #1/noquete
Boutique hotel in San Carlos
4.8 out of 5 average rating, 97 reviewsB) Beach, surf and Relax with King size bed
Boutique hotel in Playa Morillo, Mariato
4.97 out of 5 average rating, 33 reviewsDouble room IXORA with partial ocean view balcony
Nature lodge in Isla Bastimentos
4.92 out of 5 average rating, 26 reviewsBeach Bungalow on Bastimentos w/ Meals & Transport
Nature lodge in Santa Catalina
4.81 out of 5 average rating, 16 reviewsBeachfront - Private double bedroom
Nature lodge in Boca del Drago
4.82 out of 5 average rating, 11 reviewsBoca del drago room ocean front
Hotel rentals with a pool
Boutique hotel in Panamá
4.9 out of 5 average rating, 20 reviewsPool side, Family suite, two bedroom one bath.
Hotel in Playa Coronado
4.85 out of 5 average rating, 20 reviewsMy spot - Panama
Room in Panamá
4.84 out of 5 average rating, 19 reviewsRelax Room
Hostel in Panama City
4.8 out of 5 average rating, 56 reviewsEl Puente
Resort in Playa Coronado
4.88 out of 5 average rating, 8 reviewsPrivate suite with pool view
Hotel in Playa Coronado
5.0 out of 5 average rating, 5 reviewsGolf luxury mango pool suite
Nature lodge in Pueblo Nuevo
4.86 out of 5 average rating, 7 reviewsWelcome to the heart of the Panama Canal
Resort in Cañas
5.0 out of 5 average rating, 8 reviewsStandard Suite
Hotel rentals with a patio
Casa particular in Penonomé
5.0 out of 5 average rating, 4 reviewsCozy 1 br 1 bath apartment with free parking
Casa particular in Río Hato
4.5 out of 5 average rating, 4 reviewsVilla en Playa Blanca Resort Río Hato
Casa particular in Panamá
New place to stayEntire apartment
Nature lodge in San Blas Islands
4.67 out of 5 average rating, 9 reviewsNatural rooms for disconnecting
Resort in Boca Chica
4.67 out of 5 average rating, 9 reviewsLIVE WITH MONKEYS ON ISLA BOCA BRAVA (HAB.C.)
Room in Soná District
4.83 out of 5 average rating, 6 reviewsSkyRoom- Private room with shared bathroom
Room in Alto Boquete
4.8 out of 5 average rating, 5 reviewsLa casita de Elenita - sextuple room
Hotel in Panamá
New place to stayCharming Studio w/ Queen Bed
Destinations to explore
- Nature eco lodge rentals Panama
- Rentals with a sauna Panama
- Monthly Rentals Panama
- Loft rentals Panama
- Cabin rentals Panama
- Rentals with outdoor seating Panama
- Smoking-friendly rentals Panama
- Townhouse rentals Panama
- Chalet rentals Panama
- Boutique hotel rentals Panama
- Rentals with an accessible height bed Panama
- Rentals with beach access Panama
- Rentals with a fire pit Panama
- Cottage rentals Panama
- Pet-friendly rentals Panama
- Bungalow rentals Panama
- Rentals with breakfast Panama
- Rentals with a home theater Panama
- Beach condo rentals Panama
- Rentals with a patio Panama
- Serviced apartment rentals Panama
- Ski-in/ski-out rentals Panama
- Rentals with a fireplace Panama
- Fitness-friendly rentals Panama
- Treehouse rentals Panama
- Family-friendly rentals Panama
- Mansion rentals Panama
- Private suite rentals Panama
- Rentals with lake access Panama
- Bed and breakfasts Panama
- Tiny house rentals Panama
- House rentals Panama
- Rentals with an EV charger Panama
- Hostel rentals Panama
- Kid-friendly rentals Panama
- Vacation home rentals Panama
- Waterfront rentals Panama
- Farmstay rentals Panama
- Guesthouse rentals Panama
- Rentals with a washer and dryer Panama
- Beachfront rentals Panama
- Rentals with a kayak Panama
- Island rentals Panama
- Beach house rentals Panama
- Rentals with a hot tub Panama
- Wheelchair accessible rentals Panama
- Apartment rentals Panama
- Villa rentals Panama
- Condo rentals Panama
- Rentals with pools Panama
- Boat rentals Panama
- Hotel rentals Panama City
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom