Guesthouse vacation rentals in Greenville County

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Greenville County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in Travelers Rest

4.99 out of 5 average rating, 108 reviews

The Travelers Loft

Light and airy contemporary guest house with new upscale furnishings, nestled on 40 acres of woodland and meadows. Perfect for 2-4 guests. 2.5 miles from downtown Travelers Rest and the 'Swamp Rabbit Trail'. Great for biking or walking. 25 minutes to the city of Greenville and 45 to the mountains of Asheville, NC. Located less than 30 minutes from the Greenville Airport. This second story guest house has private parking, and a beautiful deck for grilling out or just relaxing after a busy day.

Guest favorite

Guesthouse in Greenville

4.92 out of 5 average rating, 633 reviews

Historic 19th Century Cabin/Guest House

This 19th century cabin is your perfect cozy getaway. This guest house is located on a 3.5 acre property, secluded from the historic neighborhood, though it's just 3 miles from downtown Greenville and the Bon Secours Wellness Arena. Less than a mile to the Swamp Rabbit Trail, this cottage is perfect for jaunts to downtown Greenville, Furman University, Paris Mountain, Travelers Rest and Unity Park! Micro weddings and events are available upon request and approval with applicable fees applied.

Guest favorite

Guesthouse in Lyman

4.99 out of 5 average rating, 145 reviews

Blue Heron Hideaway Lakeside Retreat

Welcome to this bright, lakefront space with views from every window. Enjoy kayaking, swimming, fishing, and evenings by the fire-pit. In winter, cozy up by the indoor fireplace and just relax. Take a drive into downtown Greenville, the gem of the upstate, where a walk through Falls Park and across the suspension bridge is a must! We are 15 minutes from GSP airport and BMW, in the foothills of the beautiful Blue Ridge mountains. You won’t be at a loss for things to do here in the upstate.

Guest favorite

Guesthouse in Greenville

4.99 out of 5 average rating, 391 reviews

The Cottage at Old Oaks Farm

Built in the early 1900's, this serene cottage is located approximately one mile from Furman University at the base of Paris Mt. It has been lovingly improved, but the floors are a bit slanted and no corner is exactly square. Located in a neighborhood on a five acre farm, it consists of three large rooms, comfortably furnished and lots of natural light. The cottage is convenient to downtown Greenville(5 miles),Travelers Rest, Furman, and the Swamp Rabbit Trail. No pet fee or cleaning fee.

Guest favorite

Guesthouse in Campobello

4.97 out of 5 average rating, 101 reviews

Bungalow on a 3 acre mini farm

This is a tree house like bungalow in beautiful Campobello SC. Enjoy a peaceful, rural retreat that is central to Upstate SC and Western NC. We are about 5 miles to downtown Landrum SC, 25 minutes to Spartanburg SC, 40 minutes to Greenville SC, 45 minutes to Asheville NC, and about 22 minutes to the Tryon Equestrian Center in NC. Inside the unit, downstairs is the kitchen, dining area, and bathroom, Upstairs in the loft are 4 different beds (Queen, Three Singles) &.a common area.

Guest favorite

Guesthouse in Greenville

4.93 out of 5 average rating, 192 reviews

Gorgeous Downtown Studio & Dog Friendly!

This has moved to 30 days+ starting Jan 2024! Message me if you're trying to book and your dates aren't showing available! This location is unmatched. Steps from Falls Park which includes one of the most majestic waterfalls, green space and Swamp Rabbit Trail for all your running/walking and biking needs. Directly across the street from the Greenville Drive baseball stadium. One block from all the finest restaurants, shopping and best attractions downtown offers.

Guest favorite

Guesthouse in Greenville

4.97 out of 5 average rating, 223 reviews

Greenville With A View!

ONLY 10-15 MINUTE DRIVE TO THE HEART OF BEAUTIFUL DOWNTOWN GREENVILLE! We are only 11 miles to GSP Airport; 6 miles to Greenville Downtown Airport; and 10 minutes to the Swamp Rabbit Trail. We are minutes to Furman University, Bob Jones University, North Greenville University and Clemson University is only 45 minutes away. We are tucked away open top of Paris Mountain. If you want to bike, hike, paddle, swim, boat or just soak it all in, start here!

Guest favorite

Guesthouse in Greenville

4.99 out of 5 average rating, 298 reviews

Carriage House-walk to MainSt,parking &pvt patio

45 DAY MINIMUM STAY. The Carriage House is an upstairs apartment in the quiet heart of downtown Greenville, HALF A MILE WALKING DISTANCE TO MAIN ST, close to The Well, & the Swamp Rabbit Trail. Plus plenty of private parking & a private & comfy patio. The super clean interior boasts many upgrades—new queen Casper Mattress as well as a new Zinus mattress in the sleeper sofa, fully stocked kitchen, new Sony tv with soundbar, washer/dryer, & so much more.

Guest favorite

Guesthouse in Taylors

4.98 out of 5 average rating, 128 reviews

Scandinavian Cottage

This cottage renovation has been uniquely crafted to host travelers with a modern, minimalistic, rustic, Scandinavian experience. Decorated with original wood accents, this adorable studio guesthouse is perfect for a romantic getaway, business trip or a peaceful place to unwind. It's ideally located between the well-desired cities of Greenville and Greer, SC. Foodies and adventurers alike will fall in love with this region and are sure to return.

Superhost

Guesthouse in Greenville

4.82 out of 5 average rating, 289 reviews

1950's Cottage- Close to Downtown & Furman

My 50's cottage is charming and cozy, very clean and convenient to downtown, Traveler's Rest & Furman University. Located in a quiet space with parking right beside the cottage. We are a straight shot to downtown Greenville in about 7 minutes. I listen to my awesome guests and have made a few recent updates: new electrical outlets in bathroom, new larger hot water heater for longer showers!

Guest favorite

Guesthouse in Greenville

4.92 out of 5 average rating, 223 reviews

“The Dogwood Cottage” near Greenville

This cozy little cottage is a great quick stay for a couple or even a convenient and relaxing stay for just one person. Close to downtown and great local restaurants. This Airbnb listing is shared with another listing on the same property and may see other guest coming or going. For longer stays, there is a washer and dryer available on the property for shared use.

Guest favorite

Guesthouse in Travelers Rest

4.98 out of 5 average rating, 108 reviews

Modern guesthouse in downtown TR

Steps from the Swamp Rabbit Trail, Tandem Coffee, Topsoil and more! Enjoy a stylish, relaxed stay at our centrally-located place. Whether you're an outdoor enthusiast or fun-loving foodie, you'll find something just for you nearby. Only a short drive to downtown Greenville, Furman University or Paris Mountain. Within an hour drive of Asheville and Clemson University!