
Vacation rentals in Clayton
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Top-rated vacation rentals in Clayton
Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Clayton vacation rentals
Other great vacation rentals in Clayton

Becky's Oasis-Sleeps 6/3 beds/Ballwin MO
Becky was very helpful and responsive. The house was convenient to the airport and nearby shopping.

Perfect Getaway 3BR/3BA Home
This house was so perfect for our family and our stay. We had our 3 adult children and 1 of their spouses and our baby granddaughter with us too. Since we were there for a hard, emotional time (funeral of my father-in-law), it was sooo much better to be in a house than at a hotel in separate rooms. So great to have a kitchen and plenty of space and 3 full bathrooms! When we return to St. Louis to visit again, I'd love to stay here again.

Cheerful one bedroom cottage on a horse farm
It was so nice to get away and relax for the night at the cottage! It was so peaceful! Water pressure in the shower was amazing and the bed was so comfortable! Will definitely stay again!

We do Italian STL style. Perfecto! Enjoy our NBHD!
I travel to St. Louis a few times a year to visit family with my significant other. We love “The Hill” and all the restaurants in the area. Amazing food, great area, and great people!

Modern Luxury w/Saltwater Pool / ABODEbucks
I appreciate the house. It was beautiful. It was what I expected. I will definitely Airbnb there again when I’m in town. They were very very helpful when I had questions and they answered in a timely manner thank you thank you thank you if you’re thinking about rent go ahead and do so you won’t be disappointed

Centrally Located Family Home - Park Like Yard
We had a fabulous time in Saint Louis at Scott’s place; the house is charming, clean and comfortable in a peaceful neighborhood with easy parking on the street out front. We appreciated that we could bring our dog and he absolutely loved the fenced in backyard. The kitchen was stocked with everything we would need for cooking. I highly recommend this home and hope to return soon!

Casa Italiana: Cozy home in the heart of The Hill
Joe's place is the perfect place to stay in St. Louis. The house is comfortable and exactly as described. We loved sitting on the front porch each morning and evening, the people on their walks passing by were all friendly. The Hill is a fabulous neighborhood - beautiful, convenient, and quiet. Great coffee shops and bakeries within easy walking distance. Each evening we walked to restaurants (great food for any price range). Getting Lyft or Uber was very reasonable for our destinations (downtown, Soulard, MOBOT). Will definitely book Joe's place the next time we are in St. Louis.

Quiet St Charles Cottage w/ Patio & 4 Acres
Had a great stay here, was very warm and cozy plenty of space especially if you’re traveling alone… Anita was very useful with plenty of instructions and great communication about the property.. I would highly recommend a stay here
Quick stats about vacation rentals in Clayton
Total rentals
40 properties
Nightly prices starting at
ﺩ.ﺇ184 before taxes and fees
Total number of reviews
1.6K reviews
Family-friendly rentals
20 properties are a good fit for families
Pet-friendly rentals
10 properties allow pets
Rentals with dedicated workspaces
20 properties have a dedicated workspace
Frequently Asked Questions
Where should I stay in Clayton?
Make yourself at home in Clayton by choosing from our most frequently booked neighborhoods. We have over 310 vacation rentals in Wydown Skinker, and over 310 vacation rentals in Downtown Clayton.
How much does it cost to stay in apartment rentals in Clayton?
Experience the best of Clayton with our apartment rentals, starting at about $50 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.
Are there apartment rentals with a dedicated workspace in Clayton?
Yes! Work meets play with ease at over 10 apartment rentals in Clayton featuring dedicated workspaces. Stay connected and productive in your home away from home.
Do apartment rentals in Clayton have air conditioning?
Absolutely! We offer over 20 apartment rentals with air conditioning in Clayton. Enjoy a tailored experience with all the comforts you desire.
Are there pet-friendly apartment rentals in Clayton?
Four-legged friends are welcome in Clayton. Choose from more than 10 apartment rentals for guests traveling with pets.
What are the most popular amenities for Apartment Rentals in Clayton?
Enhance your stay in our Apartment Rentals with the most popular amenities: over 20 homes with air conditioning, over 20 homes with wifi, and more. Indulge in the ultimate retreat, tailored to your preferences.
Do apartment rentals in Clayton have wifi?
Absolutely! We offer over 20 apartment rentals with wifi in Clayton. Enjoy a tailored experience with all the comforts you desire.
Are there family-friendly apartment rentals in Clayton?
Clayton has more than 10 family-friendly apartment rentals. Amenities on the property may include high chairs, travel cribs, or strollers.
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- Busch Stadium
- Enterprise Center
- Six Flags St. Louis
- Saint Louis Zoo
- Central West End
- Hidden Valley Ski Resort
- Gateway Arch National Park
- Missouri Botanical Garden
- City Museum
- St. Louis Aquarium at Union Station
- Saint Louis Science Center
- Castlewood State Park
- Cuivre River State Park
- Adventure Valley Zipline Tours and Paintball Park
- Missouri History Museum
- Boone Valley Golf Club
- The Winery at Aerie's Resort
- Pere Marquette State Park
- Bellerive Country Club
- Raging Rivers WaterPark
- Norwood Hills Country Club
- Old Warson Country Club
- Cathedral Basilica of Saint Louis
- Grafton Winery the Vineyards