Guesthouse vacation rentals in Alachua County

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for Alachua County guesthouse rentals

Family-friendly guest house rentals

Superhost
Private room in Alachua
4.91 out of 5 average rating, 35 reviews

King room at Pareners Branch Creek Guesthouse

SonjaRating, 5 stars9 months ago
This place was a perfect getaway for us. The pool area is amazing and so relaxing. My family enjoyed the pickleball and basketball. The beds were so comfortable and the room was very clean. Jane greeted us and was very friendly and accommodating. We would love to visit again.
Guest favorite
Guesthouse in Gainesville
4.87 out of 5 average rating, 211 reviews

Sunflower Acres Cottage

PeterRating, 5 stars4 days ago
Very nice place about a half hour drive from downtown Gainesville. Quiet location on a small farm in the country. Lorrie was right next door and always available but turns out I didn’t need anything.
Guesthouse in Newberry
4.98 out of 5 average rating, 46 reviews

Gator Getaway

PaulRating, 5 stars23 months ago
A great, cozy place to stay. Its the closest place you will find right next to the Easton Archery Center.
Top guest favorite
Guesthouse in Gainesville
4.97 out of 5 average rating, 541 reviews

Private Studio-Walking Distance to the UF Stadium

JohnRating, 5 stars3 days ago
I had a great stay at Ryland’s place in Gainesville. The studio was very quiet, modern, and conveniently located near UF—perfect for my weekend trip. It rained the entire time I was in town, so having a covered carport was a huge plus. Inside, everything was spotless and thoughtfully stocked with all the essentials—coffee, water, club soda, extra linens, and blankets. The studio had been fully upgraded, and the bathroom was especially sleek and modern. I also appreciated having my own private side entrance, which made everything feel even more comfortable and easy. I found a gem in Gainesville and will definitely be booking Ryland’s place again on my next visit.
Top guest favorite
Guesthouse in Gainesville
4.99 out of 5 average rating, 208 reviews

Beautiful Cottage 10 Minute Walk from UF & Stadium

CharlieRating, 5 stars3 days ago
This was a perfect 5 night stay. The house is beautiful and nothing was overlooked: laundry detergent, cooking oil, appliances, coffee, 2x wide screen TVs with cable, parking, a short walk to the UF Campus and the local bus system, and even an umbrella for the one day of rain we experienced. Rich met us upon arrival and was always responsive. This was the best lodging experience I've ever had, and I've traveled a lot.
Top guest favorite
Guesthouse in Micanopy
4.93 out of 5 average rating, 166 reviews

Private bed and bath above detached garage.

SarahRating, 5 stars1 week ago
Bob was extremely helpful and accommodating after my travel partner's unexpected 12 hour flight delay! Went above and beyond to make sure we still had an amazing weekend getaway. 15/10 will be back!

Guest house rentals with a patio

Top guest favorite
Guesthouse in Gainesville
4.97 out of 5 average rating, 77 reviews

Millhopper Modern near UF&Shands

RischenaRating, 5 stars1 week ago
The place is very nice, peaceful and quiet. All amenities were there ready for use. I would definitely stay again.
Guesthouse in High Springs
4.7 out of 5 average rating, 20 reviews

Private Detached Pool House With Kitchenette

BionquaRating, 5 stars1 month ago
Very cute little Airbnb with everything we needed for a quick visit for a wedding over the weekend. Didn’t get to use the pool but it was beautiful and available for us to use. The A/C and heat worked which was great because the weather was cold in the mornings and nights but warm during the day. The bed was very comfortable and I was grateful to have a mini fridge to store some leftovers and a microwave to reheat my food later . Great stay, I would highly recommend .
Superhost
Guesthouse in Gainesville
4.81 out of 5 average rating, 43 reviews

The house of smiles.

Natalie MarieRating, 5 stars6 days ago
The room was nice! It was okay and a good resting place. The bathroom is spacious and we are provided the basics which is great! We have all the basics in the room too! Sink, little fridge with waters, two sofas, and the two beds, and a coffee machine with coffee pods with cups. Definitely a good place to be in if you plan on using it as a resting point. Thank you for everything it made our 2 day trip nice!
Guest favorite
Guesthouse in Fort White
4.97 out of 5 average rating, 75 reviews

Horning’s Guest House -room for 14

AspenRating, 5 stars1 month ago
Lovely place for large groups, had a pool table, full kitchen, nice woods adjacent and enough beds for the listed 14 to be reasonably comfortable with a couple double ups here and there. Host was nice, place was far enough from their house to not feel like we were imposing, had a large parking space in between. We all loved the place and will be considering booking it again in the future!
Superhost
Guesthouse in Gainesville
4.59 out of 5 average rating, 17 reviews

Our Nest Cute House!

DawnRating, 5 stars1 month ago
This was a great little place to stay while visiting my daughter at college for the weekend. It was easy to find, located in a great area, and Luis was very responsive. I had no issues while staying here and would do so again in the future!
Guest favorite
Guesthouse in Gainesville
4.87 out of 5 average rating, 30 reviews

Private entrance guest suite

AlexandraRating, 5 stars3 weeks ago
Had a wonderful time staying here. The host is super sweet and responsive. Worth the money!!
Top guest favorite
Guesthouse in Gainesville
5 out of 5 average rating, 92 reviews

"Nest" in the Guest House up in the Trees near UF

DerekRating, 5 stars4 days ago
The place was really well appointed and thoughtfully put together. It was well decorated and had a lot of nice small touches, like a instruction and guide booklet, and helpful interior signage and labels (e.g., what various light switches controlled). Deborah was super communicative and accommodating. It was very clear that she wanted to make sure her guests had a really enjoyable stay. This place will be first on my list whenever I come back to the area!
Top guest favorite
Guesthouse in Micanopy
4.89 out of 5 average rating, 19 reviews

Mr. Darcy's Country French Getaway for Two

KenRating, 5 stars1 month ago
We would have liked to stay longer. This is a beautiful, quiet property that encourages relaxation.

Guest house rentals with a washer and dryer

Guest favorite
Guesthouse in Alachua
4.96 out of 5 average rating, 28 reviews

Sweetwater Studio, on 5 beautiful acres

CamillaRating, 5 stars2 months ago
Nice clean space for our quick weekend getaway. Bhishma provided clear instructions to help us arrive. We kept in touch letting him know we would be late arriving. He made sure the lights were on and the outside was nicely lit to provide Easy access to get in. Tidy and lovely space to relax, comfy beds made for a great night sleep. We drove through the small towns, enjoyed our time roaming through the quaint antique shops then to Gainesville for a little shopping and supper. Thanks Bhishma for a wonderful place to stay.
Guest favorite
Private room in Alachua
5 out of 5 average rating, 32 reviews

Cozy guest room w/double at Pareners Branch Creek

EsmeraldaRating, 5 stars1 month ago
Super sweet host, and room was incredibly cozy and I was able to feel right at home ear the beautiful Alachua scenery
Guest favorite
Guesthouse in High Springs
4.9 out of 5 average rating, 10 reviews

Mother in Law suite/Apartment @ Staycation

AntonioRating, 5 stars1 month ago
Another fantastic quick stay at this Airbnb in downtown High Springs! The location is unbeatable—just a short walk to great restaurants, shops, and coffee spots, and only a quick drive to the beautiful natural springs. The home was clean, comfortable, and had everything I needed for a relaxing stay. Whether you're here for outdoor adventures or just to enjoy the charming town, this is the perfect place to stay. I’ll definitely be back!
Guest favorite
Guesthouse in Gainesville
4.85 out of 5 average rating, 48 reviews

Cedar Guesthouse

AliRating, 5 stars4 days ago
It was a perfect location for visiting my children at the University of Florida. I had a great stay, I felt at home. The only thing was that there was no soap or shampoo, but fortunately I had brought my own. I would definitely stay there again.
Guest favorite
Guesthouse in Gainesville
4.94 out of 5 average rating, 17 reviews

One-bedroom guesthouse w/private entrance

LolaRating, 5 stars3 days ago
Sweet little guest house. Very private; in fact, we never even saw our hostess nor communicated with her while we were there, since we really didn’t need. The kitchen has all the amenities one would need. It felt like her own little home.
Top guest favorite
Guesthouse in Gainesville
4.99 out of 5 average rating, 179 reviews

Studio guesthouse in the historic Duckpond

LizzyRating, 5 stars2 weeks ago
This guest house was honestly amazing. There is a private entrance is on the other side of the main house with a great parking spot which made it feel very comfortable. The neighborhood is beautiful and peaceful, felt extremely safe. The place was extremely clean, homey, and spacious. I’d definitely recommend this guest house and would love to stay there again.
Top guest favorite
Guesthouse in Gainesville
5 out of 5 average rating, 71 reviews

Garden Cottage Sanctuary

AnneRating, 5 stars6 days ago
Laura's cottage was an idyllic place to stay while in Gainesville. The AirBnb was sparkling clean, artfully decorated and had everything we needed for our stay. The bottle of wine, basket of snacks and coffee/creamer were a wonderful bonus. The Duck Pond location was perfect and very centrally located to everything we visited in town. Thanks Laura for a fantastic stay!

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